Protein Expression Market – Trends Forecast Till 2030

Market Snapshot

Market Overview

The protein expression market size was estimated at USD 3,600 million in 2023 and is projected to reach USD 5,933.8 million in 2030 at a CAGR of 7.4 % during the forecast period 2024-2030.

The protein expression market refers to the technologies and methods used to produce proteins in cells for research, therapeutic, and industrial applications. Protein expression is critical for understanding biological processes and creating recombinant proteins, which are essential in various sectors, including pharmaceuticals, biotechnology, and agriculture. The market encompasses the development of platforms such as bacterial, yeast, mammalian, and insect cell-based systems, along with advances in gene expression technologies, to meet the growing demand for high-quality proteins.

The scope of the protein expression market is vast, covering several industries that rely on proteins for drug development, diagnostics, and therapeutic purposes. Pharmaceutical and biotechnology companies are the major drivers, as protein expression is integral to producing monoclonal antibodies, vaccines, and enzyme therapies. Additionally, the academic and research sectors utilize protein expression systems for basic research in molecular biology, genetics, and biochemistry. The growing importance of personalized medicine and biologics has expanded the market further, offering significant opportunities for growth.

Several trends are shaping the protein expression market. The adoption of automated systems for protein expression, purification, and analysis is increasing, streamlining workflows and improving efficiency. Furthermore, the demand for cell-free protein expression systems is rising due to their ability to produce proteins quickly without the need for living cells. Another key trend is the growing focus on enhancing protein yields and developing cost-effective production systems, which is driving innovations in expression systems and related technologies.

The protein expression market is driven by several factors, including the increasing demand for recombinant proteins in drug discovery and the rising prevalence of chronic diseases. Advances in genetic engineering and biotechnology have made protein expression systems more efficient and versatile, fueling market growth. Additionally, the expansion of the biotechnology industry and the rising investment in healthcare research and development are further contributing to the market's expansion. Growing awareness about the potential applications of proteins in therapeutics, diagnostics, and industrial processes is also boosting the demand for protein expression technologies globally.

Delvens Industry Expert's Standpoint

Experts in the Protein Expression Market highlight several key trends driving growth and innovation. The protein expression market involves technologies used to produce proteins for various applications in pharmaceuticals, biotechnology, and research. It is driven by the demand for recombinant proteins in drug development, diagnostics, and therapeutics, particularly in monoclonal antibody and vaccine production. Key trends include the adoption of automated systems, the rise of cell-free expression technologies, and a focus on enhancing protein yields and cost-effectiveness. The market is fuelled by advancements in genetic engineering, biotechnology, and the growing investment in healthcare R&D. As the biotechnology sector expands and awareness of protein applications increases, the protein expression market continues to grow, offering significant opportunities for innovation and development.

Market Portfolio

Key Findings

• Based on workflow, the extraction, purification, and characterization segment dominated the protein expression market in 2023. This phase, which is the final stage of the protein expression process, involves critical steps such as the isolation, purification, and verification of expressed proteins. It requires specialized reagents and advanced extraction and purification instruments, which tend to be costly. As a result, this segment held the largest market share, reflecting the high demand for these essential processes in the overall protein expression workflow.

• Based on end users, pharmaceutical and biotechnology companies led the protein expression products market in 2023. This segment accounted for the largest market share due to the increasing approval and utilization of therapeutic protein-based drugs, such as monoclonal antibodies and vaccines. The rising prevalence of chronic diseases has spurred greater research and development investments in the biotechnology and pharmaceutical sectors, driving the demand for efficient protein expression products. This growing need for innovative therapies is a key factor propelling the market growth within this segment.

• The market is also divided into various regions such as North America, Europe, Asia-Pacific, South America, and Middle East and Africa. North America region is projected to hold the largest market share. Factors such as Increasing demand for biologics, advancements in protein expression technologies, rising prevalence of chronic diseases, growing biopharmaceutical industry, expanding applications in research, increasing investments in R&D, advancements in synthetic biology, rising demand for personalized medicine, growing adoption of cell-based therapies, increasing outsourcing of protein production have triggered the Protein Expression Market in the region.

Regional Analysis

North America to Dominate the Market

• The North American protein expression market held a significant share of 35.50% in 2023, driven by the presence of major industry players, robust funding in R&D, and a strong pipeline of biosimilars. Collaborations between companies and academic institutions play a key role in this region’s growth. For example, in April 2024, Sino Biological, Inc. acquired SignalChem Biotech Inc., a move that expands both companies' product offerings and supports life science advancements, including the development of new vaccines, treatments, and diagnostic tools.

• In Europe, the protein expression market is recognized as a highly lucrative region due to increasing collaboration between academic institutions and industry players. Countries like Germany, France, and the UK are leading the innovation due to supportive regulatory frameworks for biopharmaceutical development. The growing emphasis on biologics and investments in protein engineering technologies have fueled market expansion. Additionally, Europe’s focus on sustainability has led to increased interest in plant-based protein expression systems. In May 2024, Nuclera placed its eProtein Discovery system at prominent academic institutions across Europe, including the University of Southampton and University College London.

• The Asia Pacific protein expression market is projected to experience the fastest growth rate from 2024 to 2030. This rapid growth is largely attributed to developments in India and China, where protein expression is increasingly adopted across various sectors. The focus on proteomics and genomics research, alongside growing initiatives by academic institutions to advance protein therapeutics, is expected to drive the market forward. In May 2023, WHO and the Republic of Korea signed an MOU to establish a biomanufacturing training hub, aimed at enhancing the production of biologicals in low and middle-income countries.

• The protein expression market in the Middle East and Africa is anticipated to experience significant growth in the coming years. The region is investing heavily in healthcare and biotechnology research, with countries like South Africa emerging as key players in the industry. Additionally, the Gulf Cooperation Council (GCC) nations, particularly Saudi Arabia and the UAE, are diversifying their economies through investments in biotechnology. Initiatives like Saudi Vision 2030 aim to enhance local biologics production by partnering with biotech firms, further expanding the protein expression market in the region.

Competitive Landscape

• Thermo Fisher Scientific Inc.
• Merck KGaA
• Danaher Corporation
• Agilent Technologies, Inc.
• Sartorius AG
• GenScript
• Takara Bio Inc.
• Bio-Rad Laboratories, Inc.
• Qiagen
• Charles River Laboratories
• Corning Incorporated
• Lonza
• Fujifilm Irvine Scientific, Inc.
• Syngene International Limited
• LGC Limited
• Eurofins Scientific
• Ajinomoto Co., Inc.
• Promega Corporation
• Sino Biological, Inc.
• Raybiotech, Inc.
• Bioneer Corporation
• Origene Technologies, Inc.
• New England Biolabs
• Accurus Biosciences
• Aragen Life Sciences Ltd.
• Oxford Expression Technologies Ltd
• ProteoGenix Inc.
• Abeomics

Recent Developments

• In June 2024, Thermo Fisher Scientific, Inc. (US) introduced the Thermo Scientific Stellar mass spectrometer (MS), designed to support high-throughput operations and advance translational omics research.

• In July 2024, Thermo Fisher Scientific, Inc. (US) expanded its mass spectrometry and life sciences portfolio by acquiring Olink Holding AB (Sweden), strengthening its capabilities in these areas.

• Merck KGaA (Germany) made a strategic acquisition in August 2024 by purchasing Mirus Bio (US), enhancing its viral vector manufacturing capabilities and expanding its bioprocessing portfolio through the integration of Mirus Bio's advanced transfection reagents.

• In July 2024, Merck KGaA (Germany) further expanded its footprint by opening its first GMP-compliant cell culture media (CCM) manufacturing facility at its Life Science Center in Nantong, China, reinforcing its commitment to advancing cell culture technologies.

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